1. CAS No.: 70024-90-7
2. Other Names: rHSA
3. EINECS No.: 274-272-6
4. Purity: Greater than 99 % as determined by SDS-PAGE
5. Source: Rice Grain (Oryza Sativa)
6. Formulation: OsrHSA is lyophilized with saline
7. Endotoxin: Less than 0.25EU/mg
8. Storage and Handling: Stored at temperatures 2-8℃ for 24 months
Human serum albumin is the most abundant protein in human plasma.
It can transport hormones, lipds and other molecules and maintain
osmotic pressure. Animal free rHSA is a recombinant human serum
derived from rice grains, and doesn't contain any animal component,
which is much safer than plasma derived HSA.
Human serum albumin is derived from human plasma, which is
collected from different human bodies. So we cannot guarantee the
stability of human serum albumin from different batches. Because of
this, it is difficult to apply to large-scale application in
vaccine production and cell culture. However, Healthgen uses
State-of-the-art platform, having high capacity to express proteins
and peptides in the rice grain. The platform uses rice endosperm
cells as a bioreactor to specifically and highly express various
recombinant proteins and small peptides. By using homozygous rice
as the raw material, with the world's top production process,
Healthgen can maximize the stability of albumin batches to meet the
needs of industrial production.
Physiological and Biochemical Properties of rHSA and pHSA
|Amino Acids Sequence||Same||Same|
Healthgen Biotechnology Corp. has been committed in research of
protein purification, meanwhile our technology has been patented by
the US Patent and Trademark Office on May 15th 2015 and been
granted the patent of "A method for isolating and purifying
recombinant human serum albumin from transgenic rice grain", which
patent number is US9, 023,990. Now, our rHSA purity can be as high
Based on the innovative technology, Healthgen also published
1. He Y, et al. Large-scale production of functional human serum
albumin from transgenic rice seeds. Proc Natl Acad Sci USA.
2. Zhen Chen, et al. Human serum albumin from recombinant DNA
technology: challenges and strategies. Biochimica et Biophysica
Acta. 2013; 1830: 5515-5525.
3. Zhen Chen, et al. Quantitation of the residual DNA from
rice-derived recombinant human serum albumin. Analytical
Biochemistry. 2014; 450: 4-10.
4. Jiquan Ou, et al. Transgenic rice endosperm as a bioreactor for
molecular pharming. Plant Cell Rep (2014) 33:585–594
5. Kai fu, et al. Immunotoxicity assessment of rice-derived
recombinant human serum albumin using human peripheral blood
mononuclear cells. PLoS ONE 01/2014; 9(8): e104426.